Michael D. George Author

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A Potential Role for Host-Microbe Dysbiosis in Enteropathy Associated with HIV Infection, Immune Complex Diseases

Author(s): Michael D. George

A Potential Role for Host-Microbe Dysbiosis in Enteropathy Associated with HIV Infection

Human immunodeficiency virus (HIV) infection progressively depletes CD4+ T-lymphocytes from the immune system and, in the absence of treatment, leads to acquired immune deficiency syndrome (AIDS). Gut associated lymphoid tissue (GALT) harbors a majority of the body’s lymphocytes and is an early and important mucosal target of HIV infection. The massive and rapid depletion of CD4+ T cells from GALT in primary HIV infection is presumed to be an underlying cause of a progressive deterioration of intestinal immune and digestive functions collectively termed “enteropathy”.... view more»

DOI: 10.4172/2324-853X.1000e107

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