Miguel Jr Burnier Author

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Toll-Like Receptor 3 is Expressed in All Layers of the Human Sensory Retina and Retinal Pigment Epithelium

Author(s):

Mohammed F Qutub, Pablo Zoroquiain, Shawn C Maloney, Sultan S Aldrees and Miguel Jr Burnier

Purpose: Recent studies have found that dysregulation of Toll-like receptor 3 (TLR3)-a key player in innate immunity-in retinal pigmented epithelium (RPE) may play a role in retinal oxidative stress. The aim of this study was to evaluate the expression of TLR3 in all layers of the normal human retina.

Methods: Formalin-fixed, paraffin-embedded sections of human donor eyes-with no fundoscopic or microscopic evidence of disease-were used in this study. Mean age of donors was 62.8 ± 31.5 years (12 female, 7 male). Immunohistochemistry was performed using an antibody to human TLR3 and staining was scored according to intensity (0=negative, 1=low-to-moderate, 2=strong) and extent (0=neg... view more»

DOI: 10.4172/2324-8599.1000167

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