Milton L. Brown Author
Subjects of specialization
Affiliation
Voltage-gated sodium channel, Prostate cancer, Prostate biomarker, Gleason score
Department of Oncology, drug Discovery Program, Department of Neurosciences Georgetown University Medical Center, Washington DC, USA
Milton L. Brown was worked in different sectors with more experience at Department of Oncology, drug Discovery Program, Department of Neurosciences Georgetown University Medical Center, Washington DC, USA. His current research focuses in drug discovery at Georgetown University Medical Center.
Research Article Open Access
Author(s): Simeng Suy, Todd P. Hansen, Heather D. Auto, Bhaskar V.S. Kallakury, Vernon Dailey, Malika Danner, Linda MacArthur, Ying Zhang, Matthew J. Miessau, Sean P. Collins and Milton L. Brown
Voltage-gated sodium (Nav) channels are required for impulse conductance in excitable tissues. Navs have been linked to human cancers, including prostate. The expression and distribution of Nav isoforms (Nav1.1-Nav1.9) in human prostate cancer are not well established. Here, we evaluated the expression of these isoforms and investigated the expression of Nav1.8 in human prostate cancer tissues. Nav1.8 was highly expressed in all examined cells. Expression of Nav1.1, Nav1.2, and Nav1.9 were high in DU-145, PC-3 and PC-3M cells compared to LNCaP (hormonedependent), C4-2, C4-2B, and CWR22Rv-1 cells. Nav1.5 and Nav1.6 were expressed in all c... view moreĀ»