Mohamed M Hafez | Author | SciTechnol | Endocrinology & Diabetes

Mohamed M Hafez Author

aabdelhamid@msa.eun.eg +01001425902 | +01001425902

Subjects of specialization
Metformin, Vitamin B12, Liver cells, HepG2 culture

Affiliation
Biochemistry Department, Faculty of Pharmacy, Modern Sciences and Arts University, Cairo, Egypt

Biography

Mohamed M Hafez Biochemistry Department, Faculty of Pharmacy, Modern Sciences and Arts University, Cairo, Egypt. His publications include: 1.Shaw JE, Sicree RA, Zimmet PZ (2010) Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract 87: 4-14. 2.Tilg H, Moschen AR (2006) Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 6: 772-783.

Publications

Research Article Subscription

Association of Apelin Genetic Variants with Type Two Diabetes Mellitus in Egyptian Population

Author(s):

Sherine M Ibrahim, Mohamed M Hafez, Amr M Abdelhamid

Apelin, the newly identified adipokine and the endogenous ligand for the APJ receptor is related to obesity and insulin resistance. The aim of the study was to investigate the association of 2 single-nucleotide polymorphisms (SNPs) in the apelin gene (APLN) with susceptibility to Type Two Diabetes Mellitus (T2DM) in the Egyptian population. Methods: Two SNPs on APLN were genotyped in 145 diabetic patients and 135 nondiabetic individuals, aged 40-60 years. Realtime polymerase chain reaction (RT-PCR) was used to analyze the 2 SNPs in both the diabetic and the healthy subjects. The association of the 2 SNPs (rs2281068 and rs3115759) in APLN and T2DM risk was investigated. Allele and genotype frequencies between patients and control groups were compared using the Chisquare (χ2) test. Re... view more»

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