Mohamed NA Author

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Macrophage Migration Inhibitory Factor Gene Polymorphisms (MIF-173CC) Genotyping in Patients with Cardiac Dysfunction: Relationship to Diabetes Mellitus

Author(s):

Abdelsabour M*, Idriss NK, Mohamed NA, Osama AM, Gaber MA, Alfarash A, Saad K and Elgamal DA

Introduction: Macrophage migration inhibitory factor (MIF) is an important mediator in inflammation and pathogenesis of cardiomyopathy (CMP). We aim to explore any possible association between polymorphisms of MIF genes and CMP in a cohort of Egyptian patients with cardiac dysfunction with or without diabetes mellitus and to investigate the alliance between the identified genotype and their medical features.

Patients and methods: This is a case-control study where 57 patients with CMP were consecutively admitted to CCU compared with 98 matched healthy controls. Patients were subjected to careful clinical history and physical examination, ECG, routine investigations, and echocardiography. All participants were analyzed for codon -173 G/C polymorp... view more»

DOI: 10.4172/2324-8602.1000356

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