Monika I Konaklieva | Author | SciTechnol

Monika I Konaklieva Author

Subjects of specialization
Cellular Immunology,Cell Cloning,Cell Tissue Studies,Cell Regeneration,Cell therapy

Affiliation
Associate Professor, Department of Internal Medicine

Biography

He has international experience on various programs, and also contributed and participated in different countries for diverse fields of study. Research interests reflect in wide range of publications in various national and international journals.

Publications

Short Communication Open Access

Molecular targets of b-lactams-beyond the usual suspects

Author(s):

Monika I Konaklieva

b-Lactams have historically been viewed as a class of antimicrobials. However, this paradigm is shi ing towards a focus on their ability to function as inhibitors of bacterial enzymes, particularly those involved in broad-spectrum b-lactam resistance, i.e., extended spectrum b-lactamases (ESBL). is shi in focus is the result of the recognition of the b-lactam’s ability to acylate enzymes, the majority of which have serine as nucleophile in the active site.In addition to being inhibitors of bacterial enzymes, b-lactams also inhibit viral and mammalian serine enzymes demonstrating inter-kingdom activity. e focus of this presentation is on the evaluation of the potential of b-lactam antibiotics as inhibitors of the serine enzymes of both prokaryotic and eukaryotic origin,... view more»

Abstract PDF