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Hindi Cell Biology: Research & TherapyISSN: 2324-9293
Motomu Shimaoka1 1 Author
Subjects of specialization
Affiliation
Biochemistry and Molecular Biology,Cell Cloning,Cell Regeneration,Cell Regeneration,Medicine
Department of Medicine, University of Medicine
Biography
He has international experience on various programs, and also contributed and participated in different countries for diverse fields of study. Research interests reflect in wide range of publications in various national and international journals.
Publications
Short Article Open Access
Micro-MRI-based Detection of Tissue Damage in the Liver, Pancreas, and Kidney during the Early Phases of an LPS and D-Galactosamine-Induced Hepatic Injury Model in Mice
Author(s): Nodoka Nago1*, Misao Yoneda2, Samuel Darkwah1, Eiji Kawamoto1,3, Eun Jeong Park1 and Motomu Shimaoka1
1
How tissue injuries progress among organs during LPS-induced fulminant hepatic failure remains to be elucidated, especially during the very acute phase of small animal models. We have addressed this problem in LPS/D-galactosamine-induced fulminant hepatitis by using sequential micro-MRI scanning. Analysis of T2-weighted MRI signal intensities detected tissue injury in the liver during the early phase (as early as the 3 h timepoint), at which point histological examination revealed only minor morphological changes in hepatic tissues.
In the pancreas, increases in the T2-weighted signals were made readily apparent by the pancreatic edema formation that was determined by histological examination. Only minimal pathologies were observed in the renal cortex based on micro-MRI and histo... view more»
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