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Hindi Journal of Regenerative MedicineISSN: 2325-9620
Muhammad Ary Zucha Author
Subjects of specialization
Affiliation
Obstetrics, Gynecology
Department of Obstetrics and Gynecology, Univeristas Gadjah Mada, Yogyakarta
Biography
Muhammad Ary Zucha is an medical doctor from UGM who obtained a PhD degree from Taipei Medical University. During his PhD training, he focused on doing translational research that mainly related to oncology and gynecology. They developed novel treatment modalities that specifically target cancer stem-cell. Indonesia is one of countries with largest potential of novel drug discoveries. However, only less than 2% of drugs currently developed in Indonesia. In addition to clinical and academic stuffs, He also passionate in entrepreneurship by starting-up and running my his own companies.
Publications
Review Article Subscription
TGF-β Signaling in Brain Scarring after Ischemic Stroke
Author(s): Muhammad Ary Zucha, Abdul Gofir and Pritania Astari
Excessive scarring formation in ischemic core may alter structure and function of the brain. Recent evidence found that soon after ischemic stimuli, neurovascular unit is lost and followed by recruitment of pericytes. However, the clear mechanism of the healing response is still a debate. We review the underlying mechanism of focal brain fibrosis and pericytes recruitment through TGF-β signaling in ischemic core. Moreover, TGF-β regulation to promote proliferation of vascular stromal cells and surrounding glial cells that appear in scar formation is also discussed. In this article, we review the possibility of TGF-β signaling as important regulator in Endothelial-to-mesenchymal transition (EndMT) in brain scarring, thereby future application of TGF-β inhibitor may be... view more»
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