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Hindi Endocrinology & Diabetes ResearchISSN: 2470-7570
Nicola Abate Author
Subjects of specialization
Affiliation
Medical
Professor and Chief Division of Endocrinology at University of Texas Medical Branch at Galveston
Biography
Experienced Division Chief with a demonstrated history of working in the hospital & health care industry. Skilled in Clinical Research, Medical Education, Life Sciences, Clinical Trials, and Healthcare. Strong education professional graduated from MD.
Publications
Editorial Subscription
New Insights into the Role of ENPP1 in Insulin Resistance
Author(s): Wentong Pan, Manisha Chandalia and Nicola Abate
New Insights into the Role of ENPP1 in Insulin Resistance
Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is a transmembrane glycoprotein highly expressed in adipocytes and also found in other tissues involved in glucose and lipid metabolism, including liver, skeletal muscle and beta cell of the pancreas. Early studies demonstrated that ENPP1 interacts with the insulin receptor at the level of the alpha subunit. This interaction results in decreased insulin-mediated activation of the tyrosine phosphorylation in the beta-subunit of the insulin receptor, and downstream insulin signaling activation.
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