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Hindi Journal of Clinical & Experimental OncologyISSN: 2324-9110
Patrick L Iversen Author
Subjects of specialization
Affiliation
Verapamil, Retinoic acid, Troleandomycin, Proliferation
Department of Environmental and Molecular Toxicology, Oregon State University Corvallis, OR, USA
Biography
Patrick L Iversen was working in the Department of Environmental and Molecular Toxicology, Oregon State University Corvallis, OR, USA. He has more than 50 publications. His research ork focuses in the apoptosis.
Publications
Research Article Open Access
Inhibition of Cytochrome P450 and Multidrug Resistance Proteins Potentiates the Efficacy of All-Trans Retinoic Acid in Pancreatic Cancer In Vitro and In Vivo
Author(s): Taghrid B El-Abaseri, Tarek H El- Metwally, Patrick L Iversen and Thomas E Adrian
Objectives: All-trans retinoic acid (atRA) potently induces differentiation and apoptosis in pancreatic cancer. However, the clinical use of retinoids is limited by retinoid resistance or development of toxicity at high doses. We tested the hypothesis that blocking atRA degradation and elimination from the cell would potentiate its effectiveness in pancreatic cancer therapy.
Methods: In vitro, AsPc-1 and HPAF cells were co-treated with atRA and inhibitors of either multidrug resistance (MDR: verapamil, LY335979, and quinidine) or cytochrome P450 (CYP450s: troleandomycin, clotrimazole and liarozole). In addition, cells were co treated with atRA and antisense view more»
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