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Hindi Journal of Blood Research & Hematologic Diseases
Pier Maria Fornasari Author
Subjects of specialization
Affiliation
Principle of program, Department of Curriculum, Senescence
Regen Health Solutions Research Unit, Bologna, Italy
Biography
Pier Maria Fornasari, Regen Health Solutions Research Unit, Bologna, Italy. Based on COVID-19 Chinese CDCP report on, 14% of patients presented severe disease and 5% critical conditions. The average case-fatality rate was 2,3%, but mortality was as high as 49% in patients with critical illness. Serious life threatening thromboembolic complications have been found in 71,4% of non-survivors and micro/macro angiopathic coagulopathy has been found, also at autopsy, with highly increased neutrophil number, fibrinogen, concentrations of D-dimer and FDPs and NETs, ATIII decrease and normal number of platelets.
Publications
Research Article Open Access
COVID-19: Neutrophils “Unfriendly Fire†Imbalances Proteolytic Cascades Triggering Clinical Worsening and Viral Sepsis. Potential Role Explanation for Convalescent Plasma as “Firehoseâ€
Author(s): Pier Maria Fornasari
Based on COVID-19 Chinese CDCP report on, 14% of patients presented severe disease and 5% critical conditions. The average case-fatality rate was 2,3%, but mortality was as high as 49% in patients with critical illness. Serious life threatening thromboembolic complications have been found in 71,4% of non-survivors and micro/macro angiopathic coagulopathy has been found, also at autopsy, with highly increased neutrophil number, fibrinogen, concentrations of D-dimer and FDPs and NETs, ATIII decrease and normal number of platelets. A cytokine storm and interaction between inflammation and coagulation has been advocated as explanation of hypercoagulability. The paper shows that SARS-CoV-2 infection of alveolar cells induces recruitment of innate r... view more»
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