Ping Li | Author | SciTechnol | Endocrinology & Diabetes Researc

Ping Li Author

PingLi@gmail.com

Subjects of specialization
transient receptor

Affiliation
China-Japan Friendship Hospital, China .

Biography

Ping Li is the chairman of Beijing Key Lab for ImmuneMediated Inflammatory Diseases, Institute of Clinical Medical Science, China-Japan Friendship Hospital. She has engaged in the clinical and basic research of integrated traditional Chinese

Publications

Annual Meeting Abstract Open Access

Tangshen formula alleviates hepatic steatosis by inducing autophagy through the AMPK/SIRT1 pathway

Author(s):

Ping Li

Tangshen formula (TSF), a formula of Chinese herbal medicine, improves lipid metabolism in humans and animals with diabetic kidney disease. However, the effect and mechanism of TSF on nonalcoholic fatty liver disease (NAFLD) remain unclear. The activation of autophagy appears to be a potential mechanism for improving NAFLD. In the present study, we examined the therapeutic effect of TSF on hepatic steatosis and sought to explore whether its effect is related to activating autophagy. Here, we showed that TSF treatment signifificantly attenuated hepatic steatosis in both high-fat diet (HFD) and methionine choline-defificient diet (MCDD)-fed mice. Meanwhile, TSF reduced lipid accumulation in palmitate (PA)-stimulated HepG2 cells and primary mouse hepatocytes. Furthermore, TSF increased Sir... view more»

Abstract PDF