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Hindi Journal of Regenerative MedicineISSN: 2325-9620
Reza Izadpanah3 Author
Subjects of specialization
Affiliation
Stem cells and aging
Applied Stem Cell Laboratory Heart and Vascular Institute, Department of Medicine Tulane University School of Medicine, USA
Biography
Dr. Izadpanah joined the faculty of Tulane University, where he is currently a research assistant professor in the Heart and Vascular Institute. He also holds appointments in the Department of Surgery, the Center for Aging, and Tulane Cancer Center. Currently, Dr. Izadpanah's research focuses on human mesenchymal stem cells and regenerative medicine, aging, and tumor biology.
Publications
Research Article Open Access
Adipose Derived Stem Cell Engraftment Improves Erectile Function in a Rat Model of Cavernosal Nerve Injury
Author(s): James E. Anaissie1 , Amit G. Reddy1 , Bryant Song2 , Zahra Brabadi3 , Nora M. Haney4, Fatemeh Daneshimehr3 , Travis Chen2 , Kevin Swan2 , Kenneth J. DeLay5 , Laith Alzweri5 , Philip Kadowitz2 , Bysani Chandrasekar6,7 , Eckhard U. Alt3 , Wayne J.G. Hellstrom4 and Reza Izadpanah3
Adipose-derived-stem-cells (ADSC) have shown promise in treating
erectile dysfunction (ED). Here we investigated the effect of ADSC
engraftment in restoring erectile function (EF) following nerve injury
during radical prostatectomy. Sprague-Dawley rats (4 groups; n=8/
group) underwent: 1) laparotomy (Lap) and immediate closure
(Sham); 2) Lap with bilateral cavernosal nerve injury (BCNI) (Crush);
3) Lap with BCNI and intracavernosal injection (ICI) of GFP+-ADSC
at surgery (INJ-1); and 4) Lap with BCNI and ICI of GFP+-ADSC
twice (at surgery and after three weeks) (INJ-2). Six weeks postBCNI, EF was measured via intracorporal pressure (ICP) response
following cavernosal nerve stimulation at 2.5V, 5V, and 7.5V. Penile
and... view more»
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