Journal of Regenerative MedicineISSN: 2325-9620

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Richard J Shemin Author

rshemin@mednet.ucla.edu 310-206-8232

Subjects of specialization
Thoracic Surgery, Adult Cardiac Surgery, Aortic Surgery, Cardiovascular Surgery

Affiliation
Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, USA

Biography

Dr. Shemin is currently serving as the President of the American Heart Association, Greater Boston Division and President of the Massachusetts Chapter of the Society of Thoracic Surgeons and is the immediate past President of the Northeast Cardiac Surgery Society.He is an Associate Editor for Circulation, and the Journal of Cardiac Surgery.

Publications

Research Article Subscription

Stem Cell Extracellular Matrix Interactions in Three- Dimensional System via Integrins

Author(s): Jessica M Gluck, Connor Delman, Sean Full, Richard J Shemin and Sepideh Heydarkhan-Hagvall

Stem Cell Extracellular Matrix Interactions in Three- Dimensional System via Integrins

Cells of all types interact with the extracellular matrix (ECM) through integrin-mediated interactions. Adhesion of embryonic stem (ES) cells is necessary for differentiation. We have characterized integrin expression of undifferentiated mES cells and established a system of evaluating the ECM-integrin interactions in three-dimension (3D) using electrospun scaffolds. We observed a higher proliferation rate at early time points in conventional 2D culture with various ECM proteins (collagen IV, laminin, fibronectin, vitronectin) as compared to 3D conditions. A... view more»

DOI: 10.4172/2325-9620.1000107

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