Journal of Virology & Antiviral ResearchISSN: 2324-8955

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Robert Root-Bernstein Author

Subjects of specialization
Physiological interactions, Physiology, Biomedical and Physical Sciences, Autoimmunity

Affiliation
Department of Physiology, 2174 Biomedical and Physical Sciences Building,Michigan State University, East Lansing, MI 48824 USA

Biography

Robert Root-Bernstein Affiliated to the Department of Physiology, Biomedical and Physical Sciences Building at Michigan State University, USA. His current research interests include the Peptide-neurotransmitter-drug interactions. AIDS; molecular complementarity; chemical basis of physiological interactions between peptides, monoamines, and drugs; theoretical and experimental approaches to autoimmunity and its suppression; historical and philosophical perspectives on science and its methods.


Publications

Research Article Subscription

Antigenic Complementarity between Influenza A Virus and Haemophilus influenzae may Drive Lethal Co-Infection Such as that Seen in 1918-19 Pandemic

Author(s): Robert Root-Bernstein, Abigail Podufaly and Francesco Aimone

Antigenic Complementarity between Influenza A Virus and Haemophilus influenzae may Drive Lethal Co-Infection Such as that Seen in 1918-19 Pandemic

Pfeiffer’s bacillus, now known as Haemophilus influenzae (HI), was strongly implicated in the high lethality of the 1918-19 influenza pandemic. Influenza virus (IV) infection is often complicated by (HI) super-infection and certainly was so in 1918-19. We propose that the influenza pandemic of 1918-19 was caused by concurrent pandemics of IV and HI that overwhelmed co-infected individuals through antigenic synergy between the two infections. Using T cell receptor sequences specific for IV and HI antigens, we demonstrate t... view moreĀ»

DOI: 10.4172/2324-8955.1000106

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