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Hindi Journal of Molecular Biology and Methods
Roswanira Abdul Wahab Author
Subjects of specialization
Affiliation
"Enzymes ,Microbiology ,Enzymology ,Biotransformation ,Biotechnology
Faculty of Science, Department of Chemistry, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor, Malaysia
Biography
My passion for academics has always been teaching and research. I have been lecturing since 2006, and working with students has been nothing but fun and fulfilling to the soul. What better way to live but to inspire and guide young minds through the nooks and cranny of university life. On the other hand, my research interest only began when I was halfway through my Ph.D. training. Yes, I would call it ?training.? It was then that I realized that there are so many things to do, to discover in life and that the knowledge that life offers is boundless.
Publications
Review Article Open Access
Molecular Basis and Engineering of Enzymes Stereospecificity
Author(s): Aliyu Adamu, Firdausi Aliyu, Fahrul Huyop and Roswanira Abdul Wahab
Molecular recognition, particularly enantiomeric specificity of biological molecules is a key consideration in designing drugs, pharmaceutical intermediate and in industrial production of chirally active intermediate. Although the molecular bases of many enzymes stereospecificity are not completely delineated, a number of protein engineering studies were able to enhance and even in some cases invert the stereospecificity of various enzymes. Herein, we review the current understanding on enzymes stereospecificity, and the effects of mutations to the stereospecific pockets due to enzymes engineering to improve stereospecificity.
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