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Hindi Journal of Veterinary Science & Medical DiagnosisISSN: 2325-9590
Ru Zhao Author
Subjects of specialization
Affiliation
Animal Genetics and Breeding
College of Veterinary Science, Yunnan Agricultural University, Kunming, PR China
Biography
Mr. Ru Zhao, belongs to the department of Veterinary Sciences, interest in the field of Ageing; Capillary electrophoresis; Physiological stages; Serum proteins; Sheep, from Yunnan Agricultural University, Kunming, PR China
Publications
Research Article Open Access
The irp2 Genes in High Pathogenicity Islands are Involved in the ROS Generation and Increases Antioxidase Levels in the PMNs Caused by Porcine Pathogenic Escherichia coli
Author(s): Yulin Yan, Xiangfeng Li, Zhaohui Wei, Guowen Fu, Hong Gao, Ru Zhao, Zhi yong Shao, Weijie Qu and Yongke Sun
Polymorphonuclear leukocytes (PMNs) release large quantities of reactive oxygen species (ROS) to kill pathogens. Escherichia coli (E. coli) strains containing a Yersinia high-pathogenicity island (HPI) display increased virulence that is attributable to increased iron scavenging activity, which enhances bacterial growth and limits the availability of iron for use by innate immune cells. ROS generation requires the catalysis of iron. The irp2 gene has been confirmed to be the main gene involved in the synthesis of HPI. In the present study, the effect of pathogenic HPI-positive Yunnandominant (O152) E. coli strains on the respiratory oxidative stress response from PMNs in Yunnan Saba pigs were not explored. The results showed that E. coli containing the HPI c... view more»
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