Saikat Chakrabarti Author

Research Article Open Access

Cordycepin an Adenosine Analogue Executes Anti Rotaviral Effect by Stimulating Induction of Type I Interferon

Author(s):

Shampa Deb Chanda, Anindyajit Banerjee, Satabdi Nandi, Saikat Chakrabarti and Mamta Chawla Sarkar

Abstract

Objectives:

Rotavirus is the single most common etiological pathogen of severe diarrhea in infants causing death of over half a million infants a year. In spite of such a huge disease burden, still no effective antivirals are available against rotavirus. Cordycepin (3’-deoxyadenosine), an adenosine analogue, has been reported to modulate cell proliferation, platelet aggregation and provide protection against HIV infection. Herein, attempts were made to analyze efficacy of cordycepin for protection against rotavirus and underlying mechanism.

Methods

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DOI: 10.4172/2324-8955.1000138

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