Journal of Virology & Antiviral ResearchISSN: 2324-8955

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Samina Noorali Author

shassanali@claflin.edu (+803) 535-5079

Subjects of specialization
Microbiology, Virology, Molecular Biology, Cancer Biology, viral infected cell lines

Affiliation
Department of Biology, Claflin University, 400 Magnolia Street, Orangeburg, SC, USA

Biography

 Assanie-Shivji received her Ph.D. degree in Microbiology from University of Karachi, Pakistan. Her Ph.D. research work was carried out in the Department of Pathology and Microbiology, Aga Khan University Hospital, Karachi.After submitting her Ph.D. thesis, Dr. Assanie-Shivji worked as a post-doctoral fellow in the Department of Cancer Endocrinology at BC Cancer Research Centre, Vancouver, B.C., Canada. After completing her post-doctoral work, she joined the Department of Biology at Claflin University, Orangeburg, South Carolina, USA, as a Research Assistant Professor. As a Research Assistant Professor, she established and started the functioning of Molecular Virology Laboratory.

Publications

Research Article Open Access

Human MicroRNA-602 Inhibits Hepatitis C Virus Genotype 1b Infection and Promotes Tumor Suppressor Gene Expression in a Hepatoma Cell Line

Author(s):

Samina Noorali, Kareem R Altidor, Samuel Emelife, Iqbal Mahmud, Raquel S White and Randall H Harris

Objective: Hepatitis C virus (HCV) infects 200 million people worldwide, inducing cirrhosis and hepatocellular carcinoma. Liverspecific microRNA (miR) miR-122 facilitates HCV replication, and Locked Nucleic Acid (LNA)-anti-miR-122 was used successfully as a mono-therapy in HCV infected patients. Studies show that anti-miR-122 may negatively impact hepatocyte metabolism. Previously, we showed that human (hsa) miR-602 relative intracellular expression was up-regulated in microarray profiling when transfected with HCV genotype 1b, and hsa-miR-602 lowered HCV accumulation in i... view more»

DOI: 10.4172/2324-8955.1000153

Abstract HTML PDF Supplementary File

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