Sawako Kobayashi Uchida Author

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Response-Guided Peginterferon α-2a Monotherapy for Hemodialysis Patients with Chronic Hepatitis C

Author(s): Kenjiro Yamakawa, Sawako Kobayashi Uchida, Tomoyuki Yamakawa, Akihiro Tamori and Norifumi Kawada

Response-Guided Peginterferon α-2a Monotherapy for Hemodialysis Patients with Chronic Hepatitis C

Background: Hemodialysis patients with hepatitis C virus (HCV) have a poor prognosis and ribavirin combination therapy is problematic in these patients. This study evaluated the efficacy and safety of response-guided peginterferonα-2a (PEG-IFNα-2a) monotherapy in hemodialysis patients with HCV. Associations with the IL-28B polymorphism were also examined. Methods: After 4 weeks of PEG-IFNα-2a therapy, 21 patients were allocated to two different treatment periods. Those who tested negative for HCV RNA at this point (rap... view more»

DOI: 10.4172/2324-8955.1000119

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