Senri Miwa Author

Research Article Open Access

Efficacy and Safety of Tolvaptan in Infants after Open Heart Surgery

Author(s):

Keiichi Hirose*, Senri Miwa , Hisashi Sakaguchi , Shinya Takimoto , Yukiyo Yoshida , Yohei Onga , Yuichi Tara and Kazuo Yamanaka

Background: Reports on the efficacy of tolvaptan, which is a selective vasopressin V2 antagonist, in infants who undergo cardiac surgery are rare. We evaluated the efficacy and safety of tolvaptan to manage early fluid retention in infants following open heart surgery.

Methods: Pediatric patients under the age of 1 year who underwent biventricular repair with CPB were received conventional diuretics. Additionally, tolvaptan was administered in 18 patients two days after the administration of conventional diuretics when conventional diuretics did not effectively control fluid. For the evaluation of the effect of tolvaptan, the cumulative 24-h urine volume was measured. Changes in laboratory values, cardio hemodynamic factors, and all adverse even... view more»

DOI: 10.4172/2324-8602.1000332

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