Journal of Regenerative MedicineISSN: 2325-9620

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Sepideh Heydarkhan-Hagvall Author

shagvall@mednet.ucla.edu 310-267-1885

Subjects of specialization
Cardiothoracic Surgery, Tissue Engineering

Affiliation
Department of Cardiothoracic Surgery David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, 62-151 CHS, Los Angeles, CA 90095-1741, USA

Biography

Sepideh Heydarkhan Hagvall is an Assistant Adjunct Professor in David Geffen School of Medicine at UCLA. He is working at Department of Surgery in Division of Cardiothoracic BOX 9517741, 62-151 CHS Los Angeles, CA 90095-1741. His Research Interest are Cardiothoracic Surgery , Tissue Engineering.

Publications

Research Article Subscription

Stem Cell Extracellular Matrix Interactions in Three- Dimensional System via Integrins

Author(s): Jessica M Gluck, Connor Delman, Sean Full, Richard J Shemin and Sepideh Heydarkhan-Hagvall

Stem Cell Extracellular Matrix Interactions in Three- Dimensional System via Integrins

Cells of all types interact with the extracellular matrix (ECM) through integrin-mediated interactions. Adhesion of embryonic stem (ES) cells is necessary for differentiation. We have characterized integrin expression of undifferentiated mES cells and established a system of evaluating the ECM-integrin interactions in three-dimension (3D) using electrospun scaffolds. We observed a higher proliferation rate at early time points in conventional 2D culture with various ECM proteins (collagen IV, laminin, fibronectin, vitronectin) as compared to 3D conditions. A... view more»

DOI: 10.4172/2325-9620.1000107

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