Shamma Shetye Author

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Study of HIV-1 Co-receptor Tropism and Resistance to Integrase Strand Transfer Inhibitors in the Indian Patients for Inducting New Antiretroviral Drugs in Treatment Regimens Recipient

Author(s): Pratiksha Chheda, Shamma Shetye , Priyanka Andrade and Nilesh Shah

The Human Immunodeficiency Virus (HIV) is the causal agent of the Acquired Immunodeficiency Syndrome (AIDS). The Antiretroviral therapy (ART) has been developed to identify effective inhibitors to the replication of this virus, namely viral fusion, reverse transcription and maturation, and thus cope up with the high rates of morbidity and mortality of individuals infected by it. More recently, the HIV-1 integrase and the host CCR5 receptor have become targets for ART. However, as in the case for other drug classes, Integrase Inhibitor Resistance-Associated Mutations (INI- RAMs) and mutations resulting in HIV-1 co-receptor tropism alteration has been reported resulting in the failure of these drugs. The objective of the study was to genetically analyse the RAMs within the integrase gene;... view more»

DOI: 10.4172/2324-8955.1000127

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