Cell Biology: Research & TherapyISSN: 2324-9293

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Shaolei Lu Author

Subjects of specialization
Biochemistry and Molecular Biology,Cell Cloning,Cell Regeneration,Cell Regeneration,Medicine

Affiliation
Department of Medicine, University of Medicine

Biography

He has international experience on various programs, and also contributed and participated in different countries for diverse fields of study. Research interests reflect in wide range of publications in various national and international journals.

Publications

Short Communication Open Access

GRP52 is a new sensitive markers for detecting metastatic prostatic carcinoma

Author(s):

Shaolei Lu

 

 

Metastatic prostate cancer is frequently presented as cancer of unknown origin. To confirm the prostatic origin, prostatespecific antigen (PSA), prostein, HoxB13, and NKX3.1 are frequently used. However, these markers are regulated by androgen receptor (AR) and their expression could be suppressed by hormonal therapy or altered by chemoradiation. Based on data mining of publicly available protein expression database and AR response gene database, we identified a new marker, GRP52, and compared it to the above markers in a series of metastatic prostate cancer. We collected 46 metastatic prostate tumors, including 16 bone metastases (10 treated by hormonal ablation or chemoradiation and 6 untreated) and 30 non-bone metastases (27 treated vs 3 untreated). Immunostains of all the markers we... view more»

Abstract PDF

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