Shiro Jimi Author

Short Communication Open Access

Micrograft tissue solution accelerates epidermal healing by inducing favorable tissue reactions on cutaneous wound in mice: A histopathological study

Author(s):

Shiro Jimi

We previously showed that cutaneous wound healing in normal mice is accelerated by a micrograft (MG) technique using the Rigenera protocol. Presently, clinical trials have been performed for utilizing this protocol; however, the driving mechanisms behind the beneficial effects of this approach remain unclear. In the present investigation, we focused on five major tissue reactions in wound healing in mice, namely, regeneration, migration, granulation, neovascularization and contraction. Histological data were obtained from the wounds 13 days after back skin excision and morphometrical analysis was performed. All reactions were greater in the MG group than in the control group. The wound area correlated well with granulation sizes and neovascularization densities in the granulation tiss... view more»

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