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Hindi Journal of Nephrology & Renal DiseasesISSN: 2576-3962
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SM Suhailand KT Woo Author
Subjects of specialization
Affiliation
Renal allograft
Department of Renal Medicine, Singapore General Hospital, DUKE-NUS Graduate Medical School, Academia L3, 20 College Road, 169856, Singapore
Biography
SM Suhailand KT Woo Department of Renal Medicine, Singapore General Hospital, DUKE-NUS Graduate Medical School, Academia L3, 20 College Road, 169856, Singapore. His publications include: 1. Vignali DA, Collison LW, Workman CJ (2008) How regulatory T cells work. Nat Rev Immunol 8: 523-532. 2.Calne R, Moffatt SD, Friend PJ, Jamieson NV, Bradley JA, et al. (1999) Campath 1H allows low-dose cyclosporine monotherapy in 31 cadaveric renal allograft recipients. Transplantation 68: 1613-1616.
Publications
Review Article Open Access
Paradigm Shift to Tolerance from Conventional Immunosuppression in Renal Transplant: A Basic Strategy through Lymphocyte Depletion
Author(s): SM Suhail and KT Woo
The current immunosuppressive protocols for renal allograft management, targets mainly the resident and host lymphocytes that come into play to reject the grafted tissue. This is analogous to use of antibiotics against invading microorganisms. This strategy is incomplete as the allograft under goes acute rejection episodes, and long term chronic rejection along with many of the adverse events associated with immunosuppressive medicines.
On the other hand, transplant tolerance is defined as a state of donor-specific unresponsiveness to the allograft without a need for ongoing pharmacologic immunosuppression or with a minimal use of single or dual agents. This is a paradigm shift in the allograft management. Even though impossible to achieve currently, anecdotal reports showing com... view more»
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