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Hindi Journal of Diagnostic Techniques and Biomedical AnalysisISSN: 2469-5653
Stacy Brown Author
Subjects of specialization
Affiliation
Opioids; Chromatography; Stationary phases; LC-MS; Column comparison; Therapeutic drug monitoring; Pain management
East Tennessee State University, Bill Gatton College of Pharmacy, Department of Pharmaceutical Sciences, Johnson City, USA
Biography
| Stacy Brown East Tennessee State University, Bill Gatton College of Pharmacy, Department of Pharmaceutical Sciences, Johnson City, USA |
Publications
Research Article Subscription
Comparing HPLC Stationary Phases for The Separation of Six Compounds Used in Pain Management: Is There a Viable Alternative to C18?
Author(s): Derek Stallard, Stacy Brown
Comparing HPLC Stationary Phases for The Separation of Six Compounds Used in Pain Management: Is There a Viable Alternative to C18?
In this study, four different chromatographic column chemistries (octadecylsilane/ C18, pentafluorophenyl/ PFP, octadecylated polystyrene-divinylbenzene/ PRP and underivatized silica/ HILIC) were compared under optimal conditions to evaluate the relative strengths and weaknesses of the phases for use in the determination of pain management drugs by LC-MS. Furthermore, different column scaffoldings, traditional silica, porous shell, and porous polymer, were also compared. The drugs included in this study included buprenorphine, fentanyl, methadone, naloxone, oxycodone, and tramadol. ... view more»
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