Stankova T.R Author

Annual Meeting Abstract Open Access

Carbamylation of LDL as a posttranslational modification relevant in diabetes mellitus

Author(s):

Stankova T.R

Carbamylation of LDL is a nonenzymatic posttranslational modification of LDL resulting from addition of urea-derived cyanate to either the N-terminus or ε-amino group of lysine residues in apolipoprotein B. Carbamylated LDL (cLDL) has been recently shown to manifest all of the biological effects relevant to atherosclerosis, including endothelial dysfunction, expression of adhesion molecules and vascular smooth muscle cell proliferation. In addition, cLDL binds to macrophage scavenger receptors inducing cholesterol accumulation, foam cell formation as well as enhanced oxidant generation. Despite the discovery of an alternative urea-independent myeloperoxidase-mediated mechanism for carbamylation, cLDL has been studied only in subjects with end stage renal disease. Elevated circul... view more»

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