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Hindi Journal of Nephrology & Renal DiseasesISSN: 2576-3962
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Susumu Ogawa Author
Subjects of specialization
Affiliation
?-butyrobetaine, Trimethylamine N-oxide
Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Hospital, Japan
Biography
Susumu Ogawa Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Hospital, Japan. His publications include:1.Ussher JR, Lopaschuk GD, Arduini A (2013) Gut microbiota metabolism of L-carnitine and cardiovascular risk. Atherosclerosis 231: 456-461. 2.Skagen K, Trøseid M, Ueland T, Holm S, Abbas A, et al. (2016) The Carnitine-butyrobetaine-trimethylamine-N-oxide pathway and its association with cardiovascular mortality in patients with carotid atherosclerosis. Atherosclerosis 247: 64-69.
Publications
Research Article Open Access
The Dynamics of Carnitine, γ-butyrobetaine and Trimethylamine N-oxide in Diabetics and the Effects of Changes in Renal Function
Author(s): Susumu Ogawa, Manami Shimizu, Kazuhiro Nako, Masashi Okamura and Sadayoshi Ito
Objectives: In diabetic kidney disease, vascular disorders progress alongside loss of renal function, possibly due to higher blood concentrations of angiopathic substances, such as gamma-butyrobetaine (γBB), produced by gut microbiota that feed on carnitine in dietary red meat. Therefore, we established the hypothesis that urinary γBB excretion declines with decreasing renal function, causing a rise in blood γBB concentration, leading to aggravated vascular injury.
Methods: Our subjects were non-diabetics with normal renal function (N group) and diabetics with reduced renal function (D group). We measured blood concentration and urinary γBB excretion to compare the... view more»
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