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Hindi Journal of Clinical & Experimental OncologyISSN: 2324-9110
Taghrid B El-Abaseri Author
Subjects of specialization
Affiliation
Retinoic acid, Verapamil, Troleandomycin
Department of Surgery University of Nebraska Medical Center, Omaha, NE, USA
Biography
Taghrid B El-Abaseri was working in the Department of Surgery University of Nebraska Medical Center, Omaha, NE, USA. she has more than 40 publications. Her research area focuses in Pancreatic cancer. He is specialised in Retinoic acid; Verapamil; Proliferation; Apoptosis; Pancreatic cancer
Publications
Research Article Open Access
Inhibition of Cytochrome P450 and Multidrug Resistance Proteins Potentiates the Efficacy of All-Trans Retinoic Acid in Pancreatic Cancer In Vitro and In Vivo
Author(s): Taghrid B El-Abaseri, Tarek H El- Metwally, Patrick L Iversen and Thomas E Adrian
Objectives: All-trans retinoic acid (atRA) potently induces differentiation and apoptosis in pancreatic cancer. However, the clinical use of retinoids is limited by retinoid resistance or development of toxicity at high doses. We tested the hypothesis that blocking atRA degradation and elimination from the cell would potentiate its effectiveness in pancreatic cancer therapy.
Methods: In vitro, AsPc-1 and HPAF cells were co-treated with atRA and inhibitors of either multidrug resistance (MDR: verapamil, LY335979, and quinidine) or cytochrome P450 (CYP450s: troleandomycin, clotrimazole and liarozole). In addition, cells were co treated with atRA and antisense view more»
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