Journal of Clinical & Experimental OncologyISSN: 2324-9110

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Tarek H El- Metwally Author

tadrian@uaeu.ac.ae

Subjects of specialization
Pancreatic cancer, Apoptosis, Proliferation, Troleandomycin

Affiliation
Department of Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt

Biography

Tarek H El- Metwally was working in the Department of Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt. He has more than 40 publications. His research area focuse in pancreatic cancer. He is specialised in Retinoic acid; Verapamil; Troleandomycin; Proliferation; Apoptosis; Pancreatic cancer

Publications

Research Article Open Access

Inhibition of Cytochrome P450 and Multidrug Resistance Proteins Potentiates the Efficacy of All-Trans Retinoic Acid in Pancreatic Cancer In Vitro and In Vivo

Author(s):

Taghrid B El-Abaseri, Tarek H El- Metwally, Patrick L Iversen and Thomas E Adrian

Objectives: All-trans retinoic acid (atRA) potently induces differentiation and apoptosis in pancreatic cancer. However, the clinical use of retinoids is limited by retinoid resistance or development of toxicity at high doses. We tested the hypothesis that blocking atRA degradation and elimination from the cell would potentiate its effectiveness in pancreatic cancer therapy.

Methods: In vitro, AsPc-1 and HPAF cells were co-treated with atRA and inhibitors of either multidrug resistance (MDR: verapamil, LY335979, and quinidine) or cytochrome P450 (CYP450s: troleandomycin, clotrimazole and liarozole). In addition, cells were co treated with atRA and antisense view more»

DOI: 10.4172/2324-9110.1000138

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