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Hindi Endocrinology & Diabetes ResearchISSN: 2470-7570
Teodora Stankova Author
Subjects of specialization
Affiliation
Diabetes
Department of Biochemistry, Faculty of Pharmacy, Medical University
Biography
Carbamylation of LDL is a nonenzymatic posttranslational modification of LDL resulting from addition of urea-derived cyanate to either the N-terminus or ε-amino group of lysine residues in apolipoprotein B. Carbamylated LDL (cLDL) has been recently shown to manifest all of the biological effects relevant to atherosclerosis, including endothelial dysfunction, expression of adhesion molecules and vascular smooth muscle cell proliferation.
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Conference Proceeding Open Access
Carbamylation of LDL as a posttranslational modification relevant in diabetes mellitus
Author(s): Teodora Stankova
Carbamylation of LDL as a posttranslational modification relevant in diabetes mellitus
Carbamylation of LDL is a nonenzymatic posttranslational modification of LDL resulting from addition of urea-derived cyanate to either the N-terminus or ε-amino group of lysine residues in apolipoprotein B. Carbamylated LDL (cLDL) has been recently shown to manifest all of the biological effects relevant to atherosclerosis, including endothelial dysfunction, expression of adhesion molecules and vascular smooth muscle cell proliferation. In addition, cLDL binds to macrophage scavenger receptors inducing cholesterol accumulation, foam cell formation as well as enhanced oxidant generation. Despite the discovery of an alternative urea-in... view more»
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