Terry O Harville Author

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High-Resolution (HR) HLATyping Can Confirm the Diagnosis of Graft Versus Host Disease (GVHD)After Orthotopic Liver-Transplantation (OLT)

Author(s):

Soumya Pandey, Bobbie Rhodes-Clark, Daniel Borja-Cacho,Yogesh Jethava and Terry O Harville

Acute graft versus host disease (GVHD) following orthotopic liver transplantation (OLT) is a rare but severe disease. GVHD diagnosis can often be delayed, since the symptoms are non-specific. We present a case of a 62 year-old male with end-stage liver disease who underwent OLT. There were no major peri-transplant complications. Patient presented ~4 weeks post-OLT, with fever,cough, throat discomfort, and rash; and was treated for suspected infection with broad-spectrum antimicrobials. ~5 weeks post-OLT, patient became pancytopenic, and a skin biopsy was suspicious for GVHD. Bone marrow biopsy was performed and revealed extreme pancytopenia with necrosis. The individual pre-OLT patient and donor types were compared at the serologic equivalent and high-resolu... view more»

DOI: 10.4172/2325-9612.1000143

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