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Hindi Journal of Clinical & Experimental OncologyISSN: 2324-9110
Thomas E Adrian Author
Subjects of specialization
Affiliation
Pancreatic cancer, Apoptosis, Proliferation, Troleandomycin
Department of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE
Biography
Thomas E Adrian was working in the Department of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE. He has more than 30 publications. His research work related to apoptosis.
Publications
Research Article Open Access
Inhibition of Cytochrome P450 and Multidrug Resistance Proteins Potentiates the Efficacy of All-Trans Retinoic Acid in Pancreatic Cancer In Vitro and In Vivo
Author(s): Taghrid B El-Abaseri, Tarek H El- Metwally, Patrick L Iversen and Thomas E Adrian
Objectives: All-trans retinoic acid (atRA) potently induces differentiation and apoptosis in pancreatic cancer. However, the clinical use of retinoids is limited by retinoid resistance or development of toxicity at high doses. We tested the hypothesis that blocking atRA degradation and elimination from the cell would potentiate its effectiveness in pancreatic cancer therapy.
Methods: In vitro, AsPc-1 and HPAF cells were co-treated with atRA and inhibitors of either multidrug resistance (MDR: verapamil, LY335979, and quinidine) or cytochrome P450 (CYP450s: troleandomycin, clotrimazole and liarozole). In addition, cells were co treated with atRA and antisense view more»
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