Thomas Pashuck E3 Author

Short Article Open Access

The Use of an Acellular Connective Tissue Matrix in Hindfoot and Ankle Fusions: Understanding the Cellular Bench Top Data with a Consecutive Patient Series: A Pilot Study

Author(s):

Brigido SA1*, Scott Carrington1, Protzman NM2, Yong Mao3, Thomas Pashuck E3, Joachim Kohn3 and Mohit Bhatia4
 

Abstract
Biomaterials are often used to support the healing and regeneration of bone tissue [1,2]. One of the key requirements for biomaterials/ scaffolds to be considered for bone tissue engineering is the biocompatibility and degradability of such biomaterials [3].
Placental connective tissue matrix (CTM) is a decellularized placental tissue matrix, which has minimal immunogenicity and retains the fundamental structure and functional characteristics of an intact excellular matrix. This means that CTM has the ability to provide a cell friendly environment, while allowing for the formation of endothelial channels and ultimately vascular penetration. Cellular migration and endothelial formation will ultimately cause a release of the appropriate growth factors for healing an... view more»

Abstract PDF