Journal of Clinical & Experimental OncologyISSN: 2324-9110

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Toni Jones Author

jones@gmail.com

Subjects of specialization
Benzimidazoles, Chemotherapeutic-resistant, Covalent immunochemotherapeutic, Cytotoxic anti-neoplastic potency, Dual combination anti-cancer therapy

Affiliation
Department of Basic Sciences (College of Veterinary Medicine), Mississippi State University, USA

Biography

Toni Jones was working at Department of Basic Sciences (College of Veterinary Medicine), Mississippi State University, USA. He has more than 40 publications. His current research area focusus in Benzimidazoles.

Publications

Research Article Open Access

Gemcitabine-(C4-amide)-[anti-HER2/neu] Anti-Neoplastic Cytotoxicty in Dual Combination with Mebendazole against Chemotherapeutic-Resistant Mammary Adenocarcinoma

Author(s):

C.P. Coyne, Toni Jones and Ryan Bear

Gemcitabine is a pyrimidine nucleoside analog that becomes triphosphorylated and competitively inhibits cytidine incorporation into DNA strands. Diphosphorylated gemcitabine irreversibly inhibits ribonucleotide reductase thereby preventing deoxyribonucleotide synthesis. Functioning as a potent chemotherapeutic, gemcitabine decreases neoplastic cell proliferation and induces apoptosis which accounts for its effectiveness in the clinical treatment of several leukemia and carcinoma cell types. A brief plasma half-life due to rapid deamination, chemotherapeutic-resistance and sequelae restrict gemcitabine utility in view more»

DOI: 10.4172/2324-9110.1000109

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