Toshikazu Kondo Author

Short Communication Open Access

CC chemokine ligand-2 (CCL2) accelerates skin wound healing in diabetic mice

Author(s):

Toshikazu Kondo

Wound healing is a complex but well-regulated biological phenomenon and is composed of three phases such as inflammation, proliferation and maturation. In each phase of wound healing process, immune cells, mesenchymal cells and parenchymal cells play important roles through the production of biological substances, extracellular matrix and so on. Especially, chemokines can contribute to the normal wound healing process by regulating the spatiotemporal recruitment of distinct types of leukocytes. Wound healing is influenced by various kinds of systemic and local factors. Hyperglycemia is one of the major factors that have negative influence on skin wound healing. Thus, diabetic patients often show complications such as impaired skin wound repair. CCL2 is the major chemokine which recruit ... view more»

Abstract