Journal of Virology & Antiviral ResearchISSN: 2324-8955

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Tracey M. Doyle Author

TraceyM@hc-sc.gc.ca

Subjects of specialization
Influenza, Neuraminidase, Biochemistry, Microbiology

Affiliation
Centre for Vaccine Evaluation, Biologics and Genetic Therapies Directorate,HPFB, Health Canada, Ottawa, ON, Canad

Biography

Tracey Doyle is a Ph.D. candidate at the University of Ottawa in the department of Biochemistry, Microbiology and Immunology.  She now shows that monoclonal antibodies against this region are the first to universally inhibit neuraminidase activity and influenza growth both in vitro and in vivo. Her data supports the candidacy of neuraminidase as an antigen in universal vaccine research. Tracey completed her B.Sc at the University of Waterloo and her M.Sc at McMaster University in Hamilton. 

Publications

Editorial Open Access

Alternative Roles of Neuraminidase in Influenza a Viral Propagation

Author(s):

Tracey M. Doyle and Sean (Xuguang) Li

Alternative Roles of Neuraminidase in Influenza a Viral Propagation

Influenza A is an envelope virus containing a segmented negative RNA genome. The viral envelope has two major surface glycoproteins, Hemagglutinin (HA) and Neuraminidase (NA) of which there are 16 and 9 subtypes respectively. While HA has been well characterized and shown to be essential for viral fusion and entry into host cells, the functional roles of NA in viral replication are much less understood. Some previous reports suggest that NA exerts its primary role during viral exit from the cell by enzymatically cleaving sialic acid and facilitating the release of viral particles from the ... view more»

DOI: 10.4172/2324-8955.1000e104

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