Ursula Rauch | Author | SciTechnol | Cell Biology: Research & Th

Ursula Rauch Author

ursularauch@charite.de +49 30 450 513 736 | +49 30 450 5

Subjects of specialization
Thrombocardiology,Metabolomics,Cell Death: Apoptosis,Hematology,Medicine

Affiliation
Senior Physician, Thrombocardiology ,Charit

Biography

Ursula Rauch is a Senior Physician, Thrombocardiology Charit� ? Universit�tsmedizin Berlin, Campus Benjamin Franklin, Centrum f�r Herz- und Kreislaufmedizin, Berlin, Germany. Regulation of the Tissue Factor Isoform Expression and Thrombogenicity of HMEC-1 by miR-126 and miR-19a

Publications

Research Article Open Access

Regulation of the Tissue Factor Isoform Expression and Thrombogenicity of HMEC-1 by miR-126 and miR-19a

Author(s):

Andreas Eisenreich and Ursula Rauch

Regulation of the Tissue Factor Isoform Expression and Thrombogenicity of HMEC-1 by miR-126 and miR-19a

Endothelial cells modulate the vascular wall homeostasis and blood thrombogenicity. Inflammatory conditions induce the Tissue Factor (TF) isoform expression and cellular thrombogenicity in endothelial cells. MicroRNAs (miRNAs) posttranscriptionally regulate gene expression. MiRNA-19 (miR-19) was shown to downregulate the TF expression in breast cancer cells. The role of miRNAs, such as miR-19a or the endothelial cellspecific miR-126 in the modulation of the endothelial TF expression and activity is unknown.

DOI: 10.4172/2324-9293.1000101

Abstract HTML PDF