Walid A Mawla Author

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The Value of FAK and SLUG Expression in Patients with Breast Carcinoma and Relation of Their Expression to Clinicopathological and Prognostic Parameters

Author(s):

Mona S Mohamed, Ola A Harb*, Nashwa Nawar, Heba F Taha, Samar A Amer, Eman A Eltokhy , Loay M Gertallah, Walid A Mawla and Doaa M Abdelmonem

Background: Although there is marked improvement in breast carcinoma (BC) management, it is still the leading cause of cancer death in middle-aged and old females, which leads to emergence of many studies about recent prognostic biomarkers that aimed to discover new therapeutic targets for BC. Focal adhesion kinase (FAK) is a member of protein tyrosine kinase (PTK) family. Slug is a member of the Snail family that is a C2H2-type zinc-finger transcription factor and plays an essential role in Epithelialmesenchymal transition [EMT] process activation in cancer.

Our study aimed: To evaluate FAK and SLUG expressions in BC, to correlate their expressions with differentiation, invasiveness, met... view more»

DOI: 10.4172/2324-9110.1000218

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