Endocrinology & Diabetes ResearchISSN: 2470-7570

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Wentong Pan Author

niabate@utmb.edu 409-772-6314

Subjects of specialization
 Division of Endocrinology, ,Stark Diabetes Center

Affiliation
Department of Medicine, Division of Endocrinology, Stark Diabetes Center, Institute for Translational Science (ITS), The University of Texas Medical Branch at Galveston, Texas, USA

Biography

Manisha Chandalia is working in Department of Medicine, Division of Endocrinology, Stark Diabetes Center, Institute for Translational Science (ITS), The University of Texas Medical Branch at Galveston, Texas, USA

Publications

Editorial Subscription

New Insights into the Role of ENPP1 in Insulin Resistance

Author(s):

Wentong Pan, Manisha Chandalia and Nicola Abate

New Insights into the Role of ENPP1 in Insulin Resistance

Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is a transmembrane glycoprotein highly expressed in adipocytes and also found in other tissues involved in glucose and lipid metabolism, including liver, skeletal muscle and beta cell of the pancreas. Early studies demonstrated that ENPP1 interacts with the insulin receptor at the level of the alpha subunit. This interaction results in decreased insulin-mediated activation of the tyrosine phosphorylation in the beta-subunit of the insulin receptor, and downstream insulin signaling activation.

... view more»

DOI: 10.4172/2325-9736.1000e103

Abstract HTML PDF

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