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Hindi Cell Biology: Research & TherapyISSN: 2324-9293
Xinyun Li Author
Subjects of specialization
Affiliation
Cellular Immunology,Metabolomics,Cell Tissue Studies,Cell Regeneration
Associate Professor, Department of Internal Medicine
Biography
He has international experience on various programs, and also contributed and participated in different countries for diverse fields of study. Research interests reflect in wide range of publications in various national and international journals.
Publications
Short Communication Open Access
Three functional mutation sites affect the immune response of pigs through altering the expression pattern and IgV domain of the CD4 protein
Author(s): Xinyun Li
The CD4 protein is an important surface marker of T lymphocytes, which can mediate the antigen presentation process by interacting with MHC II and TCR molecules in human and mouse.
In this study, two haplotypes (A and B) of the CD4 gene were found within Chinese indigenous and Western commercial pig breeds. These two haplotypes were defined by 22 fully linked SNPs in the CDS region of the CD4 gene. The expression level and localization of the CD4 protein were significantly different between haplotypes A and B. Transcriptome analysis revealed that the immune response-related genes and signaling pathways were down-regulated in genotype AA. Finally, three linked functional SNPs were identified, which affected the expression level and membrane lo... view more»
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