Journal of Clinical & Experimental OncologyISSN: 2324-9110

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Ying Zhang Author

mb544@georgetown.edu

Subjects of specialization
Mucoepidermoid carcinoma, Cancer chemotherapy, Prostate biomarker

Affiliation
Department of Biostatistics, Georgetown University Medical Center, Washington DC, USA

Biography

Ying Zhang was working in the Department of Biostatistics, Georgetown University Medical Center, Washington DC, USA. Doctor has more than 40 publications. Doctor's current research area related to clinical oncology.

Publications

Research Article Open Access

Expression of Voltage-Gated Sodium Channel Nav1.8 in Human Prostate Cancer is Associated with High Histological Grade

Author(s):

Simeng Suy, Todd P. Hansen, Heather D. Auto, Bhaskar V.S. Kallakury, Vernon Dailey, Malika Danner, Linda MacArthur, Ying Zhang, Matthew J. Miessau, Sean P. Collins and Milton L. Brown

Voltage-gated sodium (Nav) channels are required for impulse conductance in excitable tissues. Navs have been linked to human cancers, including prostate. The expression and distribution of Nav isoforms (Nav1.1-Nav1.9) in human prostate cancer are not well established. Here, we evaluated the expression of these isoforms and investigated the expression of Nav1.8 in human prostate cancer tissues. Nav1.8 was highly expressed in all examined cells. Expression of Nav1.1, Nav1.2, and Nav1.9 were high in DU-145, PC-3 and PC-3M cells compared to LNCaP (hormonedependent), C4-2, C4-2B, and CWR22Rv-1 cells. Nav1.5 and Nav1.6 were expressed in all c... view more»

DOI: 10.4172/2324-9110.1000102

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