Journal of Virology & Antiviral ResearchISSN: 2324-8955

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Research Article, J Virol Antivir Res Vol: 3 Issue: 4

Basant, a Polyherbal Topical Microbicide Candidate Inhibits different Clades of Both CCR5 and CXCR4 Tropic, Lab-Adapted and Primary Isolates of Human Immunodeficiency Virus-1 in Vitro Infection

Maciej B Maselko1,2, Rupali S Joshi3, Meagan Prescott1, GP Talwar4, Smita Kulkarni3, Manoj K.Pastey1*
1Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA
2Molecular and Cellular Biology Program, Oregon State University, Corvallis, Oregon, USA
3National AIDS Research Institute, Pune. 73, G Block, MIDC, Bhosari, Pune – 411 026, India
4Talwar Research Foundation, E-8, Neb Valley, Neb Sarai, New Delhi 110068, India
Equal Contribution.
Corresponding author : Manoj K. Pastey
210 Dryden Hall, Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon 97331, USA
Tel: (541)737-3940; Fax: (541)737-2730
E-mail: [email protected]
Received: March 21, 2014 Accepted: November 07, 2014 Published: November 12, 2014
Citation: Maselko MB, Joshi RS, Prescott M, Talwar GP, Kulkarni S, et al.(2014) Basant, a Polyherbal Topical Microbicide Candidate Inhibits different Clades of Both CCR5 and CXCR4 Tropic, Lab-Adapted and Primary Isolates of Human Immunodeficiency Virus-1 in Vitro Infection. J Virol Antivir Res 3:4. doi:10.4172/2324-8955.1000131

Abstract

Topical microbicides applied to the vaginal mucosa as pre-exposure prophylactic measures for controlling sexually transmitted diseases have great potential to combat theHIV-1 pandemic in the developing world. Basant is a polyherbal topical microbicide candidate with demonstrated activity against CXCR4 co-receptor tropic HIV-1 as well as fungal and bacterial sexually transmitted infections. The current study demonstrates that Basant is effective against both CCR5 and CXCR4 tropic HIV-1 lab-adapted strains and primary isolates from different clades. We also investigate the kinetics of Basant inhibition as compared to the fusion inhibitor Enfuvirtide and report that Basant inhibits HIV-1 at an early stage of infection. We conclude that Basant may be considered as a potential candidate for use as an effective vaginal microbicide in preventing HIV-1 transmission

Keywords: HIV-1 ;Topical microbicides

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