Journal of Liver: Disease & TransplantationISSN: 2325-9612

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Editorial, J Liver Dis Transplant Vol: 1 Issue: 2

Cancer Associated Fibroblasts and Hepatocellular Carcinoma

Eunice Yuen Ting Lau1,2, Irene Oi Lin Ng1,2 and Terence Kin Wah Lee1,2*
1State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong
2Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
Corresponding author : Dr. Terence K.W. Lee
Department of Pathology, Li Ka Shing Faculty of Medicine Room 704, 7/F, Faculty of Medicine Building, 21 Sassoon Road, The University of Hong Kong, Hong Kong
Tel: (852) 2819-9390; Fax: (852) 2819-5375
E-mail: [email protected]
Received: November 15, 2012 Accepted: November 16, 2012 Published: November 20, 2012
Citation: Lau EYT, Ng IOL, Lee TKW (2012) Cancer Associated Fibroblasts and Hepatocellular Carcinoma. J Liver: Dis Transplant 1:2. doi:10.4172/2325-9612.1000e104

Abstract

Cancer Associated Fibroblasts and Hepatocellular Carcinoma

Hepatocellular Carcinoma (HCC) ranks the fifth most common cancer worldwide, and high recurrent rate and metastasis are the major hurdles for effective therapies of this disease. Recently, increasing evidence shows that Cancer-associated Fibroblasts (CAFs), one of the most abundant cell types inside the tumor stroma, plays a prominent role in progression of various cancer types. Since most of the HCC cases are developed with cirrhosis background in which activated myofibroblast is enriched, the role of CAFs in HCC progression is currently being investigated.

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