Journal of Traumatic Stress Disorders & TreatmentISSN: 2324-8947

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Case Report, J Trauma Stress Disor Treat Vol: 3 Issue: 2

Clozapine for Treatment- Resistant Post-Traumatic Stress Disorder (PTSD)

Harmony Raylen Abejuela1,2,3*, Fe Erlita Festin1,2 and Lynn Es DeLisi1
1Veterans Affairs (VA) Boston Healthcare System, USA
2Department of Psychiatry, Harvard Medical School, USA
2Harvard South Shore (HSS) Psychiatry Residency Training Program, USA
Corresponding author : Harmony Raylen Abejuela
Harvard South Shore (HSS), Psychiatry Residency Training Program, VA Boston Healthcare System (116 A-7), 940 Belmont Street, Brockton, MA 02301, USA
Tel: 774-826-2458; Fax: 774-826-1859
Received: July 22, 2013 Accepted: February 28, 2014 Published: March 11, 2014
Citation: Abejuela HR, Festin FE, DeLisi LE (2014) Clozapine for Treatment-Resistant Post-Traumatic Stress Disorder (PTSD). J Trauma Stress Disor Treat 3:2. doi:10.4172/2324-8947.1000120


Clozapine for Treatment- Resistant Post-Traumatic Stress Disorder (PTSD)

Clozapine is approved by the Food and Drug Administration (FDA) for treatment of schizophrenia, has been used off-label for treatment of patients with bipolar disorder, and has been shown to reduce suicidal ideation. However, because of its various adverse effects, clozapine has not been adequately explored for treatment of other psychiatric disorders, particularly in suicidal post-traumatic stress disorder (PTSD) patients. Suicidal PTSD patients are challenging, given their multiple inpatient psychiatric hospitalizations and numerous failed medication trials. It is possible that clozapine may be a useful treatment for suicidal PTSD patients, particularly when other treatments have failed.


Keywords: Post-traumatic stress disorder (PTSD); Treatment-resistant; Clozapine; Suicide; Psychosis

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