International Journal of Ophthalmic PathologyISSN: 2324-8599

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Research Article, Int J Ophthalmic Pathol Vol: 4 Issue: 1

Diagnosis of Cysticercosis in Eye and Treatment Follow-Up of Extra Ocular Forms by Serum IgG ELISA

Priyadarshi Soumyaranjan Sahu1,3*, Pramod Kumar Sahu2,4 and Subhash Chandra Parija1
1Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry-605006, India
2Department of Ophthalmology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry-605006, India
3Department of Pathology, School of Medicine, International Medical University, 57000 Kuala Lumpur, Malaysia
4Department Ophthalmology, UCMS and Guru Teg Bahadur Hospital, Shahdara, New Delhi-110095, India
Corresponding author : Priyadarshi Soumyaranjan Sahu
Division of Pathology, School of Medicine, International Medical University, 57000 Kuala Lumpur, Malaysia
E-mail: [email protected]
Received: October 10, 2014 Accepted: December 05, 2014 Published: December 11, 2014
Citation: Priyadarshi SS, Pramod KS, Subhash CP (2015) Diagnosis of Cysticercosis in Eye and Treatment Follow-Up of Extra Ocular Forms by Serum IgGELISA. Int J Ophthalmic Pathol 4:1. doi:10.4172/2324-8599.1000154

Abstract

Ophthalmic cysticercosis (OCC) caused by Taenia solium larval infection in eye, is emerging as a far commoner disease in the tropics. There is a scarcity in sero diagnostics to aid its laboratory diagnosis; thereby management still continues to pose a serious challenge. Presently serum IgG-ELISAs were performed on 40 consecutive clinically diagnosed OCC cases. Extra ocular muscle was found to be the predominant site of infection where ocular motility disorder was the major clinical presentation. ELISA using larval somatic and excretory secretory (ES) antigens was positive in 32.5% and 45% cases respectively. Anti-ES antibodies were detected more frequently in cases having extra ocular cysts compared to intraocular location. Differential levels of antibodies specific to above two antigens were estimated during the course of parasite degeneration as evident from findings following treatment. These indigenous serum IgG ELISAs might be useful as an adjunct to existing tools for diagnosis of OCC with a more promising application in post treatment follow up of extra ocular form of cysticercosis in particular.

Keywords: Cysticercus cellulosae; Taenia solium; Intraocular; Extra ocular; Ophthalmic cysticercosis; ELISA

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