Journal of Clinical & Experimental OncologyISSN: 2324-9110

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Case Report, J Clin Exp Oncol Vol: 4 Issue: 1

Diagnostic and Therapeutic Challenges in IgG4-Related Disease in the Sphenoid Sinus

Omar A Abu Suliman1*, Tariq Aidarous2, Osama Marglani3 and Adel Banjar4
1Department of Otolaryngology Head and Neck surgery, King Abdullah Medical City, Makkah, Saudi Arabia
2Department of Otolaryngology Head and Neck Surgery, Al Noor Specialist Hospital, Makkah, Saudi Arabia
3College of Medicine, Umm Al Qura University, Makkah, Saudi Arabia
4Department of Otolaryngology Head and Neck Surgery, Ohud General Hospital, Madinah, Saudi Arabia
Corresponding author : Omar A Abu Suliman
Department of Otolaryngology Head & Neck surgery, King Abdullah Medical City, Makkah, Saudi Arabia
Tel: +966555505152
Received: March 31, 2015 Accepted: May 26, 2015 Published: June 01, 2015
Citation: Suliman OAA, Aidarous T, Marglani O, Banjar A (2015) Diagnostic and Therapeutic Challenges in IgG4-Related disease in the Sphenoid Sinus. J Clin Exp Oncol 4:1. doi:10.4172/2324-9110.1000137


Immunoglobulin G4 (IgG4) related disease is a newly recognized fibro inflammatory condition characterized by tumefactive lesions, a dense lymphoplasmacytic infiltrate rich in IgG4-positive plasma cells, storiform fibrosis and often but not always, elevated serum IgG4 concentrations. We present a 38 years old female complaining of headache which was progressive and unilateral resistant to analgesics. Diagnosed as a case of migraine started anti migraine treatment with no benefit, it was further complicated by 3rd, 4th and 6th Cranial Palsy. Radiological finding of opacification of left sphenoid sinus with extension to the left cavernous sinus along with bone erosion was noted. The biopsy from the sphenoid sinus mass showed a moderately dense lymphoplasmacytic infiltration accompanied with fibrosis. Immunostaining for IgG4 show significant increase in IgG4-positive plasma cells with IgG4-IgG ratio > 40% and >100 IgG4 positive plasma cells per High Field Focus (HPF), giving the diagnosis of IgG4 sinusitis. This is a rare case of IgG4 related disease in the sphenoid sinus. Clinical, radiological and therapeutic challenges are discussed.

Keywords: Immunoglobulin G4; IgG4; Sphenoid, Sinus; Migraine

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