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Journal of Veterinary Science & Medical Diagnosis ISSN: 2325-9590

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Research Article, J Vet Sci Med Diagn Vol: 3 Issue: 1

Diagnostic Enzyme Aided Assessment of Cytotoxicity Induced by an Acute Dose of Clenbuterol in Mice Tissues

Manju Kaundal1* and Sushma Sharma2
1Ishar Jyot Degree College Pehowa, Kurukshetra, Haryana, India
2Department of Biosciences, HP University, Shimla, Himachal Pradesh, India
Corresponding author : Dr. Manju Kaundal
Assistant Professor of Zoology, Ishar Jyot Degree College Pehowa, Kurukshetra, Haryana, India
Tel: 01741221692
E-mail: [email protected]
Received: November 25, 2013 Accepted: February 06, 2014 Published: February 11, 2014
Citation: Manju K, Sushma S (2014) Diagnostic Enzyme Aided Assessment of Cytotoxicity Induced by an Acute Dose of Clenbuterol in Mice Tissues. J Vet Sci Med Diagn 3:1. doi:10.4172/2325-9590.1000129

Abstract

Diagnostic Enzyme Aided Assessment of Cytotoxicity Induced by an Acute Dose of Clenbuterol in Mice Tissues

All the drugs when administered orally have to pass though liver before reaching the target organ due to portal system. Clenbuterol is a β-adrenergic drug which is well-known for its muscle anabolic effects. Present study was therefore planned to examine the effects of acute dose of clenbuterol on mice liver, heart (cardiac muscles) and gastrocnemius (skeletal muscle). This was achieved by measuring the levels of two important marker enzymes used in diagnosis of various pathological conditions i.e. Lactate dehydrogenase (LDH) and creatine kinase (CK). The biochemical assays were further supported by a fluorescent assay to measure cell necrosis.

Keywords: Clenbuterol; Lactate dehydrogenase; Creatine kinase; Liver; Heart; Necrosis; Apoptosis; Gastrocnemius

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