Journal of Liver: Disease & TransplantationISSN: 2325-9612

Reach Us +1 850 900 2634
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Research Article, J Liver Dis Transplant Vol: 2 Issue: 1

The Effect of Genetic Variations of Methylene Tetrahydropholate Reductase Gene Polymorphisms on Ribavirin-Induced Anemia in Hepatitis C Patients

Zuhal Mert Altintas1*, Engin Altintas2, Orhan Sezgin2, Tuba Gokdogan Edgunlu1, Enver Ucbilek2, Erdinc Nayir3, Ibrahim Omer Barlas1 and Mehmet Emin Erdal1
1Department of Medical Biology and Genetics, Mersin University School of Medicine, Mersin, Turkey
2Department of Gastroenterology, Mersin University School of Medicine, Mersin, Turkey
3Department of Internal Medicine, Mersin University School of Medicine, Mersin, Turkey
Corresponding author : Zuhal Mert Altintas
Department of Medical Biology and Genetics, Mersin University School of Medicine, Mersin, Turkey
Tel: +90-324-361-00-01/1136; Fax: +90-324-361-00-00
E-mail: [email protected]
Received: December 14, 2012 Accepted: March 21, 2013 Published: March 25, 2013
Citation: Altintas ZM, Altintas E, Sezgin O, Edgunlu TG, Ucbilek E, et al. (2013) The Effect of Genetic Variations of Methylene Tetrahydropholate Reductase Gene Polymorphisms on Ribavirin-Induced Anemia in Hepatitis C Patients. J Liver: Dis Transplant 2:1. doi:10.4172/2325-9612.1000108

Abstract

The Effect of Genetic Variations of Methylene Tetrahydropholate Reductase Gene Polymorphisms on Ribavirin-Induced Anemia in Hepatitis C Patients

Ribavirin is a purine nucleoside analogue. Even though its mechanism of action is still controversial, it widely prevents the replication of DNA and RNA viruses through the inhibition of inosine monophosphate dehydrogenase, an essential enzyme in the synthesis of guanosine triphosphate. Currently, the treatment of patents with hepatitis C consists of interferon-α and ribavirin combination therapy.

Keywords: Anemia; Hepatitis C; Methylenetetrahydrofolate reductase; Ribavirin; S- adenosylhomocysteine hydrolase

Track Your Manuscript

Share This Page